WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene
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منابع مشابه
WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger transcription factor that has been demonstrated to negatively regulate several growth factor and cognate receptor genes. However, inconsistent with its tumor suppressor function, WT1 has also been demonstrated to be required to inhibit programmed cell death in vitro and in vivo. Moreover, anaplastic Wilms' tumors, which typically expr...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 0261-4189,1460-2075
DOI: 10.1093/emboj/18.14.3990